[Solved] Error relaunching VirtualBox VM Process: 5 | VirtualBox won't start

In this article we are going to discuss about the 'supR3HardenedWinReSpawn' error. When i was exploring the Cisco IOU tool, I had to import a Cisco IOU VM which was in OVF file format. But as soon as i double click the ovf file, VM refused to start and an error popped up, saying:

Error in supR3HardenedWinReSpawn

Result Code: E_FAIL (0x80004005)

Component: Machine

Interface: IMachine {480cf695-2d8d-4256-9c7c-cce4184fa048}

And another message was also given in addition to the above,

Error relaunching VirtualBox VM process: 5

Command line: '81954AF5-4D2F-31EB-A142-B7AF187A1C41-suplib-2ndchild--comment Fedora32 --startvm fd699e30-a77b-4eac-8ced-1210d756855d --no-startvm-errormsgbox' (rc=-104)

The error that you receive might not be as exact as it's given here, since VM details are also part of the error. For example,

If you look at the error shown above, My VM name 'GNS3 IOU VM' is also part of the error. 

Why do I see this error ?

Well, When i was doing a little research on this topic, i found out that this error might show up because of any one of the below points. 

  1. It could be an issue with the VirtualBox version that you are trying on, I found the latest VirtualBox version 5 to be very buggy. 
  2. It might be your Antivirus which causes this error.
  3. It might be because of your registry settings.

How to resolve this E_FAIL (0x80004005) error ?

Try the below solutions one by one,

Solution 1:

Find the below entry in Registry Editor and delete it.

[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers] "C:\Program Files\Oracle\VirtualBox\VirtualBox.exe"="DISABLEUSERCALLBACKEXCEPTION"

Solution 2:

Uninstall or Disable your Antivirus software.

Solution 3:

If the above 2 solutions did not work, Try degrading the degrading the VirtualBox to version 4.3.12 from the version that you are currently running. You can download VirtuablBox 4.3.12 from this link. https://www.virtualbox.org/wiki/Download_Old_Builds_4_3_pre24

If you still face this issue, I would recommend you to try the other desktop virtualization softwares like Vmware Workstation or Hyper--V.

I hope this post helps you to solve the mentioned error. 

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Hey there! I'm Senthil Kumar Murugesan, An Infrastructure engineer with a focus on Cisco Unified Communications and Hacking. Also I’m happy to mention that I’m a Linux junkie, a Cisco proponent, a Tools fanatic and Script lover. This is a blog, a rambling of thoughts, and a result of technical experiments


  1. I've also faced this same error while initiating VirtualBox, but before following this complicated steps first check for any update of VirtualBox either manually or by 'Check for Update' [ Prefer manual method because inbuilt method will check only major update (e.g., 4.2.0 to 4.3.0), not maintenance updates (e.g., 5.0.4 to 5.0.8) ]......
    Secondly uninstall & reinstall VirtualBox and finally reboot.....
    But your second step to disable or uninstall antivirus is common & necessary..[ Prefer to disable & If one can't disable it, then turn off OS & Online Protection ]

  2. Many thanks for this article Senthil

  3. thanks for this answer. step 1 and step 2 is not working .so ....

  4. https://play.google.com/store/apps/details?id=com.extractor.getapk.backup

  5. Hi, thank you for your explanation, I have found my solution by enabling Virtualization feature on my BIOS on CPU settings. This can fix this error in case one of these on this topic not work.

  6. downgrading to 4.3.12 worked for me (using win7 x64 bit on a HP Elite laptop)

  7. Stupid pop up adds.

  8. I found the solution. Delating the entry in Registry Editor or Disabling AV doesn't work for me. Try this: go to folder ...VirtualBox\drivers\vboxdrv, right click VBoxDrv.inf, install, then restart your PC, done! You are welcome


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